What is HHC? Frequently Asked Questions about HHC (Hexahydrocannabinol)
Hexahydrocannabinol (HHC) is a semi-synthetic cannabinoid that has recently emerged in the European drug market. First described in the scientific literature in 1940, HHC is chemically similar to Δ9-tetrahydrocannabinol (Δ9-THC), the main psychoactive substance in cannabis. Despite its long history, HHC has only recently been identified in Europe, with its first appearance in May 2022.
What is HHC?
HHC is synthesized from cannabidiol (CBD), which is extracted from low-THC cannabis (hemp). It is sold openly as a 'legal' replacement for cannabis and THC products. The substance is available in various forms, including low-THC cannabis flower and resin that have been sprayed or mixed with HHC, vapes, and food products, such as sweets.
Laboratory studies in vitro and in several animal species in vivo suggest that HHC has broadly similar effects to cannabis and THC products. However, the pharmacology and toxicology of HHC in humans have not been studied, and it does not appear to have documented legitimate uses.
The Legal Status of HHC
HHC is not scheduled under the 1961 and 1971 UN Conventions. In the European Union (EU), HHC is monitored as a new psychoactive substance (NPS) by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) through the Early Warning System (EWS). At the time of writing this BLOG, HHC was not controlled in most EU Member States.
The Emergence of HHC in the Market
The emergence of HHC in the market is linked to changes in legislation, particularly in the US, where the legalisation of hemp cultivation led to an abundant supply of hemp and CBD, which can be used as a precursor for semi-synthetic cannabinoids like HHC.
HHC was first sold in the US around September 2021 and was identified in 70% of the EU Member States between May and December 2022. It is marketed as a 'legal' replacement for cannabis and THC products, with advertising often making direct comparisons or allusions to similarities in effects between the substances.
The EMCDDA's Response
The EMCDDA has responded to potential public health and social risks from this new market with a range of actions, including the production of a technical report that provides authoritative information on HHC and closely related substances. These actions are intended to strengthen awareness of this emerging issue and to support preparedness and response measures at national and EU levels.
Conclusion
The rise of HHC and related substances represents a new development in the cannabinoid market. While these substances offer a 'legal' alternative to cannabis and THC products, their effects and potential risks are not fully understood. As such, further research is needed to explore the full biological activity spectrum of this cannabinoid and to develop methods for the rapid and unambiguous detection of HHC or its metabolites in urine.
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What is HHC? Frequently Asked Questions about HHC (Hexahydrocannabinol)
Hexahydrocannabinol (HHC) is a semi-synthetic cannabinoid that has recently emerged in the European drug market. First described in the scientific literature in 1940, HHC is chemically similar to Δ9-tetrahydrocannabinol (Δ9-THC), the main psychoactive substance in cannabis. Despite its long history, HHC has only recently been identified in Europe, with its first appearance in May 2022.
What is HHC?
HHC is synthesized from cannabidiol (CBD), which is extracted from low-THC cannabis (hemp). It is sold openly as a 'legal' replacement for cannabis and THC products. The substance is available in various forms, including low-THC cannabis flower and resin that have been sprayed or mixed with HHC, vapes, and food products, such as sweets.
Laboratory studies in vitro and in several animal species in vivo suggest that HHC has broadly similar effects to cannabis and THC products. However, the pharmacology and toxicology of HHC in humans have not been studied, and it does not appear to have documented legitimate uses.
The Legal Status of HHC
HHC is not scheduled under the 1961 and 1971 UN Conventions. In the European Union (EU), HHC is monitored as a new psychoactive substance (NPS) by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) through the Early Warning System (EWS). At the time of writing this BLOG, HHC was not controlled in most EU Member States.
The Emergence of HHC in the Market
The emergence of HHC in the market is linked to changes in legislation, particularly in the US, where the legalisation of hemp cultivation led to an abundant supply of hemp and CBD, which can be used as a precursor for semi-synthetic cannabinoids like HHC.
HHC was first sold in the US around September 2021 and was identified in 70% of the EU Member States between May and December 2022. It is marketed as a 'legal' replacement for cannabis and THC products, with advertising often making direct comparisons or allusions to similarities in effects between the substances.
The EMCDDA's Response
The EMCDDA has responded to potential public health and social risks from this new market with a range of actions, including the production of a technical report that provides authoritative information on HHC and closely related substances. These actions are intended to strengthen awareness of this emerging issue and to support preparedness and response measures at national and EU levels.
Conclusion
The rise of HHC and related substances represents a new development in the cannabinoid market. While these substances offer a 'legal' alternative to cannabis and THC products, their effects and potential risks are not fully understood. As such, further research is needed to explore the full biological activity spectrum of this cannabinoid and to develop methods for the rapid and unambiguous detection of HHC or its metabolites in urine.