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Kanna (Sceletium tortuosum) is a psychoactive plant from South Africa traditionally chewed, snorted, and drunk as tea by the Khoikhoi. Kanna is sometimes compared to MDMA due to certain social and euphoric user experiences.
Kanna (Sceletium tortuosum) is a succulent plant native to South Africa. The plant contains various alkaloids, of which mesembrine and mesembrenone are the best known. These substances affect the serotonin system, among other things. For example, mesembrine inhibits the reuptake of serotonin, while mesembrenone also influences the PDE4 enzyme.
Because it is a natural product, the quantity and ratio of these alkaloids can vary per plant and product. This is also why two kanna extracts with the same name or strength do not automatically produce the same effect.
Kanna can have both stimulating and relaxing properties. Users often describe the initial part of the effect as more active and social, after which it transitions into calm and relaxation. Some people also report a warm or slightly euphoric feeling, an increased desire for social contact, and heightened sensitivity to touch.
Kanna is regularly compared to MDMA online and sometimes even nicknamed ‘nature’s MDMA’. This comparison mainly stems from the social and somewhat empathogenic effects some users experience. However, there are important differences. MDMA causes a strong release of serotonin, among other things, and typically has a much more intense stimulating, euphoric, and empathogenic effect. The main alkaloids in kanna primarily inhibit serotonin reuptake. Kanna is generally experienced as much more subtle.
The comparison therefore mainly says something about certain subjective effects and not that kanna and MDMA have the same mechanism of action, strength, or risks. Combining both substances is strongly discouraged.
Kanna is traditionally chewed, snorted, and used as tea. Today, there are also extracts, gummies, capsules, and blends.
Kanna affects neurotransmitters in the brain and is therefore not without risks. Relatively little good research has been done, especially on high doses, strong extracts, daily use, and combinations with other psychoactive substances.
The legal status of kanna can vary significantly by country and product composition. Legislation is subject to change; always check the current local regulations of the destination country before purchase and use.
10x, 20x, and 40x are used to denote different concentrations of kanna extract. A higher x-value generally indicates a more concentrated extract.
ET2 and UB40 are different types of kanna extracts and not strength indicators like 10x or 20x. ET2 is a fine and highly concentrated extract typically with a mesembrine-rich profile. UB40 has a coarser structure and is offered, among other things, for use in a vaporizer.
There is no fixed duration of action for kanna. How quickly the effect begins and how long it lasts depends, among other things, on the product form, concentration, method of use, and personal sensitivity. Therefore, always follow the information provided with the specific product.
Combining is discouraged. Do not use kanna without medical consultation in combination with serotonergic antidepressants such as SSRIs and SNRIs or with MAO inhibitors. Combinations with MDMA, alcohol, cannabis, and other psychoactive substances can also produce unpredictable or enhanced effects.
Insufficient research exists to properly determine the risk of dependence with long-term use. Daily use is therefore discouraged. Needing more and more, having difficulty stopping, or feeling that you need kanna to feel good can be signs of problematic use.